2014 Meeting

The International Narcotics Research Conference 2014

Dates: July 13 (Sun) to July 18 (Fri), 2014


NEW - FINAL Scientific Program (pdf)

Speakers List for INRC 2014 Meeting (pdf)

scientific program

Sunday July 13th

3PM-9PM       Registration

6PM-9PM       Welcome reception

Monday July 14th

 Plenary lecture #1

8AM-9AM       Roger Sunahara (University of Michigan)

 “Structural and functional characterization of the receptor-G protein cooperativity”

 Symposium #1

9AM-12PM  Receptor crystal structure and novel opioid chemistry

Chair: Peter Schiller (Institut de Recherche Clinique de Montréal)      

Discussion leader: Ivy Carroll (Research Triangle Institute)

                Gustavo Fenalti (Scripps Research Institute)

“Molecular Control of Opioid Receptor Signaling”

Nurulain Zaveri (Astraea Therapeutics)

“Which way is up? Rethinking Nociceptin Ligand Design and SAR From Nociceptin Opioid Receptor Crystal Structure and Active-State Homology Model comparisons”

Philip Portoghese (University of Minnesota)

“MOR heteromers as targets for treatment of inflammatory and neuropathic pain”

Stephen Husbands (University of Bath)

“Relapse prevention: targeting multiple receptors”


Hot Topics (2-3 speakers to be selected from the abstracts)

 Symposium #2

1PM-4PM   Revisiting the therapeutic potential of delta opioid receptor ligands

                Chair:  Junzo Kamei (Hoshi University)                

Discussion leader: Emily Jutkiewicz (University of Michigan)

Gregory Scherrer (Stanford University School of Medicine)

“Delta Opioid Receptor Function in Skin: Controlling Pain Where it Starts”

Jon Violin (Trevena Inc.)

“Biased ligands at mu and delta opioid receptors: targeting selective signalling to develop improved therapeutics”

Manojkumar Puthenveedu (Carnegie Mellon University)

“Increasing delta opioid receptor bioavailability”

Amynah Pradhan (University of Illinois at Chicago)  

“The Potential of Delta Opioid Receptor Agonists for the Treatment of Migraine”


Hot Topics (2-3 speakers to be selected from the abstracts)

 4PM-6PM       Poster session #1 

Tuesday July 15th

Founder’s lecture

8AM-9AM    Brigitte Kieffer (McGill University) and

Christopher Evans (University of California Los Angeles)

“Cloning: twice in one day”

Symposium #3

9AM-12PM  Changes in reward circuitry in chronic pain. 

                Chair: Howard Fields (University of California San Francisco) 

Discussion leader: Catherine M. Cahill (University of California Irvine)


Marco L. Loggia (Harvard Medical School)

"Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia"

Lucia Hipolito (Columbia University)

“Chronic pain increases opioid self-administration through an accumbal dopaminergic mechanism”

Anna Taylor (University of California Irvine)

“Neuropathic Pain Modulates Dopaminergic Circuitry: Role for Microglial Activation”

Zhizhong Pan (University of Texas)

Pain facilitates response to opioid reward via a shared epigenetic pathway”


Hot Topics (2-3 speakers to be selected from the abstracts)

Symposium #4

1PM-4PM    Dissecting the functions of Nociceptin/Orphanin FQ receptors

                Chair: Michael Bruchas  (Washington University)          

Discussion leader: Larry Toll (Torrey Pines Institute)

Raül Andero Galí (Emory University)

“Amygdala-dependent fear is regulated by opioid receptor-like 1 in mice and humans with PTSD”

Kelly Standifer (University of Oklahoma College of Pharmacy)

“Neuroinflammatory actions of N/OFQ following traumatic stress”

Thomas Jhou (Medical University of South Carolina)

“Nociceptin/Orphanin-FQ in the rostromedial tegmental nucleus”

Talakad Lohith (National Institutes of Mental Health)

“Imaging of nociceptin/orphanin FQ peptide (NOP) receptors in human brain and whole-body using a novel positron emission tomography radioligand, [11C]NOP-1A”


Hot Topics (2-3 speakers to be selected from the abstracts)

4PM-6PM       Poster session #2 

Wednesday July 16th

 Plenary lecture #2

8AM-9AM       Antonello Bonci (NIDA intramural program director)

                        “Optogenetic approaches to study synaptic plasticity and substance abuse”

 Symposium #5

9AM-12PM  Dysphoria and aversion in addiction and chronic pain

                Chair: Chris Evans (University of California Los Angeles)

                Discussion leader: Charles Chavkin (University of Washington)

Bryan Roth (University of North Carolina)

“Do biased k-opioid agonists differ from unbiased agonists in dysphoric potential?”

Julie Kauer (Brown University)

“Acute stress activates kappa opioid receptors and triggers persistent synaptic changes in the VTA”

Joel Schlosburg (Scripps Research Institute, San Diego)

“Dynorphin-kappa opioid receptor activation regulates the dynamics of drug-taking in the progression towards addiction”

Brendan Walker (Washington State University)

“Quiescent kappa-opioid receptors in the medial prefrontal cortex: the rollercoaster of cognitive control”


Hot Topics (2-3 speakers to be selected from the abstracts)

 12-1:30PM     Data Blitz 

Free afternoon 

Thursday July 17th

 Plenary lecture #3

8AM-9AM       Yves De Koninck (Université Laval)

“Expanding your toolbox; new approaches to probe the brain with light”

 Symposium #6

9AM-11AM  Workshop on new technologies in neuroscience and drug


Chair: Fred Nyberg (Uppsala University)

Discussion leader: Jose Moron-Concepcion (Columbia University)

Maxime Descoteaux (Université de Sherbrooke)

“Diffusion MRI : imaging the wiring of the brain”

Philippe Seguela (McGill University)

"Optogenetic control of pain pathways in vivo"

Sotiris Masmanidis (University of California Los Angeles)

“Large-scale electrophysiology and virtual reality for reward circuit research”


Hot Topics (2-3 speakers to be selected from the abstracts)

Symposium #7

11AM-2PM  Young Investigator Award symposium

Dissecting Opioid Neural Circuits

                 Chair: John Traynor (University of Michigan)

 Discussion leader: Elyssa Margolis (University of California San Francisco)

Michael Bruchas (Washington University)

“Spatiotemporal Control of Opioid Systems in Reward and Aversion”

Thomas Kash (University of North Carolina)

“Dynorphin controls the gain of an amygdalar anxiety circuit

Matthew Banghart (Harvard University)

“A photochemical approach to peptidergic neuromodulation”


Hot Topics (2-3 speakers to be selected from the abstracts)

Symposium #8

2PM-5PM    Genetic and epigenetic regulation in addiction and chronic pain

Chair: Laura Stone (McGill University)

Discussion leader: Mary Jeanne Kreek (The Rockefeller University)

Luda Diatchenko (McGill University)

“Expansion of mu-opioid receptor gene locus: new functional variants”

Jörn Lötsch (Johann Wolfgang Goethe-Universität)

“Genetic and epigenetic regulation in addiction and chronic pain”

Pamela Kennedy (University of California Los Angeles)

“Chromatin Cross-Talk in the Nucleus Accumbens: Implications for Cocaine-Induced Behavioral and Molecular Adaptations”

Marcello Wood (University of California Irvine)

“The role of HDAC3 in acquisition and extinction of drug-seeking behavior”


Hot Topics (2-3 speakers to be selected from the abstracts)

5PM-6PM       Business meeting

7PM-late         Banquet Dinner 

Friday July 18th

                        End of the Conference and Departure


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